Clarian Health Ventures Portfolio

Celleration is a revenue stage medical device company which develops and markets proprietary technology that accelerates healing in chronic and hard-to-heal wounds. The Company’s core product, the MIST Therapy System (“MIST”), is FDA-approved and delivers therapeutic, low-frequency ultrasound without direct wound surface contact. The MIST system is comprised of a reusable capital device used in conjunction with a disposable saline applicator applied on a per treatment basis.

CS Keys, Inc. is a development stage biotechnology company focused on the discovery and development of cancer-specific biomarkers to be used to enhance the diagnosis and treatment of patients with cancer. The company’s first product is an immunohistochemistry (IHC) stain that will identify cancer cells with a dark brown color, while non-cancerous cells remain blue, allowing for the diagnosis of cancer at earlier stages and with greater certainty.

The company’s product development pipeline also includes a blood test (ELISA) to help monitor a patient’s remission status. The company is also pursuing the development of a future therapeutic product.

Endocyte is a drug development company. The company is combining its proprietary technology with existing chemotherapy drugs, to better target the drugs to cancer tissue while avoiding damage to healthy tissue.

iScience Interventional, Inc. is based in Menlo Park, CA, and is the leader in the development of innovative microcatheter platforms that enable specific treatment of ocular disease. The iScience iTrack Canaloplasty Microcatheter™ platform used to treat open-angle glaucoma is commercially available in the United States, Canada and Europe. Clinical evaluation of the iCATH™ platform for the treatment of wet-AMD is currently underway at selected sites in Europe.

MedVentive provides leading-edge technology solutions that enable physician groups, integrated delivery systems, health plans and self-insured employers to effect meaningful and measurable change in the quality and cost of the care they deliver to patients.

My Healthcare Manager ("MHCM") is an early stage, national consumer health care system provider that has developed proprietary software (Senior Care Navigation System-SCANS) for the management of geriatric care. MHCM has developed software, four distribution channels, and a network of service providers that can provide assessments and/or deliver services throughout the United States. MHCM provides comprehensive case management for the elderly, including a situational assessment, maintenance of a Personal Health Record, and timely communication to family members and providers through a secure web site that permits encrypted transactions. Software developed by the company supports records and case management, and facilitates remote monitoring by family members.

NeoChord is an early stage medical device company commercializing a minimally invasive surgical tool to implant artificial chordae tendineae as a treatment for mitral valve regurgitation. NeoChord has an exclusive worldwide license from Mayo Clinic to develop and distribute the technology, which has been successfully used in two patients under a compassionate device use exemption.

NICO Corporation, formed in October 2007 and based in Indianapolis, IN, is dedicated to developing technology for the field of minimally invasive neurosurgery, including skull base and spinal surgery. Their technology and products are designed and developed to positively impact patient’s lives, their families, the care giver, and the health system provider.

Noxilizer has developed a unique and proprietary medical sterilization process based on a combination of nitrogen dioxide (NO2) and nitrogen oxide (NO). Noxilizer’s sterilization technology addresses two large market segments: biotherapeutics and hospitals.

Quadraspec has developed and exclusively licensed Purdue technology that permits high-volume testing of lab samples, utilizing laser interferometry that will dramatically increase the volume of tests (“multiplexing”) that can be performed in the lab, on an automated basis.